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Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting
Between the 1950s and 1980s, scientists were focusing mostly on how the genetic code was transcribed to RNA and translated to proteins, but how proteins were degraded had remained a neglected research area. With the discovery of the lysosome by Christian de Duve it was assumed that cellular proteins...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rambam Health Care Campus
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707415/ https://www.ncbi.nlm.nih.gov/pubmed/23908826 http://dx.doi.org/10.5041/RMMJ.10068 |