Deprenyl Enhances the Teratogenicity of Hydroxyurea in Organogenesis Stage Mouse Embryos

Hydroxyurea, an antineoplastic drug, is a model teratogen. The administration of hydroxyurea to CD1 mice on gestation day 9 induces oxidative stress, increasing the formation of 4-hydroxy-2-nonenal adducts to redox-sensitive proteins such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the ca...

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Detalles Bibliográficos
Autores principales: Schlisser, Ava E., Hales, Barbara F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707438/
https://www.ncbi.nlm.nih.gov/pubmed/23696560
http://dx.doi.org/10.1093/toxsci/kft115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707438/
https://www.ncbi.nlm.nih.gov/pubmed/23696560
http://dx.doi.org/10.1093/toxsci/kft115

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