Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model

BACKGROUND: The cardiac PRKAG2 mutation in the γ2-subunit of adenosine monophosphate activated kinase (AMPK) is characterized by excessive glycogen deposition, hypertrophy, frequent arrhythmias, and progressive conduction system disease. We investigated whether myocardial glucose uptake (MGU) was au...

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Detalles Bibliográficos
Autores principales: Thorn, Stephanie L, Gollob, Michael H, Harper, Mary-Ellen, Beanlands, Rob S, deKemp, Robert A, DaSilva, Jean N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707764/
https://www.ncbi.nlm.nih.gov/pubmed/23829931
http://dx.doi.org/10.1186/2191-219X-3-48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707764/
https://www.ncbi.nlm.nih.gov/pubmed/23829931
http://dx.doi.org/10.1186/2191-219X-3-48

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