The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus Polymerase

T-705 (Favipiravir) is a broad-spectrum antiviral molecule currently in late stage clinical development for the treatment of influenza virus infection. Although it is believed that T-705 potency is mediated by its ribofuranosyl triphosphate (T-705 RTP) metabolite that could be mutagenic, the exact m...

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Detalles Bibliográficos
Autores principales: Jin, Zhinan, Smith, Lucas K., Rajwanshi, Vivek K., Kim, Baek, Deval, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707847/
https://www.ncbi.nlm.nih.gov/pubmed/23874596
http://dx.doi.org/10.1371/journal.pone.0068347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707847/
https://www.ncbi.nlm.nih.gov/pubmed/23874596
http://dx.doi.org/10.1371/journal.pone.0068347

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