Unique Mechanism of the Interaction between Honey Bee Toxin TPN(Q) and rKir1.1 Potassium Channel Explored by Computational Simulations: Insights into the Relative Insensitivity of Channel towards Animal Toxins

BACKGROUND: The 21-residue compact tertiapin-Q (TPN(Q)) toxin, a derivative of honey bee toxin tertiapin (TPN), is a potent blocker of inward-rectifier K(+) channel subtype, rat Kir1.1 (rKir1.1) channel, and their interaction mechanism remains unclear. PRINCIPAL FINDINGS: Based on the flexible featu...

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Detalles Bibliográficos
Autores principales: Hu, Jun, Qiu, Su, Yang, Fan, Cao, Zhijian, Li, Wenxin, Wu, Yingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707903/
https://www.ncbi.nlm.nih.gov/pubmed/23874410
http://dx.doi.org/10.1371/journal.pone.0067213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707903/
https://www.ncbi.nlm.nih.gov/pubmed/23874410
http://dx.doi.org/10.1371/journal.pone.0067213

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