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Unique Mechanism of the Interaction between Honey Bee Toxin TPN(Q) and rKir1.1 Potassium Channel Explored by Computational Simulations: Insights into the Relative Insensitivity of Channel towards Animal Toxins
BACKGROUND: The 21-residue compact tertiapin-Q (TPN(Q)) toxin, a derivative of honey bee toxin tertiapin (TPN), is a potent blocker of inward-rectifier K(+) channel subtype, rat Kir1.1 (rKir1.1) channel, and their interaction mechanism remains unclear. PRINCIPAL FINDINGS: Based on the flexible featu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707903/ https://www.ncbi.nlm.nih.gov/pubmed/23874410 http://dx.doi.org/10.1371/journal.pone.0067213 |