Lentiviral miR30-based RNA Interference against Heparanase Suppresses Melanoma Metastasis with Lower Liver and Lung Toxicity

Aim: To construct short hairpin RNAs (shRNAs) and miR30-based shRNAs against heparanase (HPSE) to compare their safety and their effects on HPSE down-modulation in vitro and in vivo to develop a more ideal therapeutic RNA interference (RNAi) vector targeting HPSE. Methods: First, we constructed shRN...

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Detalles Bibliográficos
Autores principales: Liu, Xiao-yan, Tang, Qiu-su, Chen, Hong-chao, Jiang, Xiao-ling, Fang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708037/
https://www.ncbi.nlm.nih.gov/pubmed/23847439
http://dx.doi.org/10.7150/ijbs.5425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708037/
https://www.ncbi.nlm.nih.gov/pubmed/23847439
http://dx.doi.org/10.7150/ijbs.5425

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