Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous studies of transcriptional profiling have revealed biologically relevant GBM subtypes associated with specific mutations and dysregulated pathways. Here, we applied a modified proteome to uncover abn...

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Autores principales: Haskins, William E., Zablotsky, Bethany L., Foret, Michael R., Ihrie, Rebecca A., Alvarez-Buylla, Arturo, Eisenman, Robert N., Berger, Mitchel S., Lin, Chin-Hsing Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708153/
https://www.ncbi.nlm.nih.gov/pubmed/23875172
http://dx.doi.org/10.3389/fonc.2013.00182
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author Haskins, William E.
Zablotsky, Bethany L.
Foret, Michael R.
Ihrie, Rebecca A.
Alvarez-Buylla, Arturo
Eisenman, Robert N.
Berger, Mitchel S.
Lin, Chin-Hsing Annie
author_facet Haskins, William E.
Zablotsky, Bethany L.
Foret, Michael R.
Ihrie, Rebecca A.
Alvarez-Buylla, Arturo
Eisenman, Robert N.
Berger, Mitchel S.
Lin, Chin-Hsing Annie
author_sort Haskins, William E.
collection PubMed
description Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous studies of transcriptional profiling have revealed biologically relevant GBM subtypes associated with specific mutations and dysregulated pathways. Here, we applied a modified proteome to uncover abnormal protein expression profile in a MRI-classified group I GBM (GBM1), which has a spatial relationship with one of the adult neural stem cell niches, subventricular zone (SVZ). Most importantly, we identified molecular characteristics in this type of GBM that include up-regulation of metabolic enzymes, ribosomal proteins, and heat shock proteins. As GBM1 often recurs at great distances from the initial lesion, the rewiring of metabolism, and ribosomal biogenesis may facilitate cancer cells’ growth and survival during tumor progression. The intimate contact between GBM1 and the SVZ raises the possibility that tumor cells in GBM1 may be most related to SVZ cells. In support of this notion, we found that markers representing SVZ cells are highly expressed in GBM1. Emerged findings from our study provide a specific protein expression profile in GBM1 and offer better prediction or therapeutic implication for this multifocal GBM.
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spelling pubmed-37081532013-07-19 Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme Haskins, William E. Zablotsky, Bethany L. Foret, Michael R. Ihrie, Rebecca A. Alvarez-Buylla, Arturo Eisenman, Robert N. Berger, Mitchel S. Lin, Chin-Hsing Annie Front Oncol Oncology Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous studies of transcriptional profiling have revealed biologically relevant GBM subtypes associated with specific mutations and dysregulated pathways. Here, we applied a modified proteome to uncover abnormal protein expression profile in a MRI-classified group I GBM (GBM1), which has a spatial relationship with one of the adult neural stem cell niches, subventricular zone (SVZ). Most importantly, we identified molecular characteristics in this type of GBM that include up-regulation of metabolic enzymes, ribosomal proteins, and heat shock proteins. As GBM1 often recurs at great distances from the initial lesion, the rewiring of metabolism, and ribosomal biogenesis may facilitate cancer cells’ growth and survival during tumor progression. The intimate contact between GBM1 and the SVZ raises the possibility that tumor cells in GBM1 may be most related to SVZ cells. In support of this notion, we found that markers representing SVZ cells are highly expressed in GBM1. Emerged findings from our study provide a specific protein expression profile in GBM1 and offer better prediction or therapeutic implication for this multifocal GBM. Frontiers Media S.A. 2013-07-11 /pmc/articles/PMC3708153/ /pubmed/23875172 http://dx.doi.org/10.3389/fonc.2013.00182 Text en Copyright © 2013 Haskins, Zablotsky, Foret, Ihrie, Alvarez-Buylla, Eisenman, Berger and Lin. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Oncology
Haskins, William E.
Zablotsky, Bethany L.
Foret, Michael R.
Ihrie, Rebecca A.
Alvarez-Buylla, Arturo
Eisenman, Robert N.
Berger, Mitchel S.
Lin, Chin-Hsing Annie
Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme
title Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme
title_full Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme
title_fullStr Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme
title_full_unstemmed Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme
title_short Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme
title_sort molecular characteristics in mri-classified group 1 glioblastoma multiforme
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708153/
https://www.ncbi.nlm.nih.gov/pubmed/23875172
http://dx.doi.org/10.3389/fonc.2013.00182
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