Cargando…

Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells

Oxidation of cysteine residues to disulfides drives import of many proteins into the intermembrane space of mitochondria. Recent studies in yeast unraveled the basic principles of mitochondrial protein oxidation, but the kinetics under physiological conditions is unknown. We developed assays to foll...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fischer, Manuel, Horn, Sebastian, Belkacemi, Anouar, Kojer, Kerstin, Petrungaro, Carmelina, Habich, Markus, Ali, Muna, Küttner, Victoria, Bien, Melanie, Kauff, Frank, Dengjel, Jörn, Herrmann, Johannes M., Riemer, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708723/ https://www.ncbi.nlm.nih.gov/pubmed/23676665 http://dx.doi.org/10.1091/mbc.E12-12-0862

Ejemplares similares

Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space
por: Kojer, Kerstin, et al.
Publicado: (2015)

Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol
por: Klöppel, Christine, et al.
Publicado: (2011)

Protein oxidation in the intermembrane space of mitochondria is substrate-specific rather than general
por: Peleh, Valentina, et al.
Publicado: (2014)

Oxidative Folding in the Mitochondrial Intermembrane Space in Human Health and Disease
por: Fraga, Hugo, et al.
Publicado: (2013)

MEMBRANE JUNCTIONS IN THE INTERMEMBRANE SPACE OF MITOCHONDRIA FROM MAMMALIAN TISSUES
por: Saito, Akitsugu, et al.
Publicado: (1974)

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria
por: Schreiner, Bernadette, et al.
Publicado: (2012)

Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2
por: Liu, Peipei, et al.
Publicado: (2017)

In vitro import of cytochrome c peroxidase into the intermembrane space: release of the processed form by intact mitochondria
Publicado: (1989)

Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease
por: Chatzi, Afroditi, et al.
Publicado: (2016)

Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding
por: Kritsiligkou, Paraskevi, et al.
Publicado: (2017)

Protein Translocation into the Intermembrane Space and Matrix of Mitochondria: Mechanisms and Driving Forces
por: Backes, Sandra, et al.
Publicado: (2017)

Ionic strength of the intermembrane space of intact mitochondria as estimated with fluorescein-BSA delivered by low pH fusion
Publicado: (1991)

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo
por: Erdogan, Alican J., et al.
Publicado: (2018)

Intermembrane Space Proteome of Yeast Mitochondria
por: Vögtle, F.-Nora, et al.
Publicado: (2012)

The Mia40/CHCHD4 Oxidative Folding System: Redox Regulation and Signaling in the Mitochondrial Intermembrane Space
por: Dickson-Murray, Eleanor, et al.
Publicado: (2021)

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space
por: Mattie, Sevan, et al.
Publicado: (2018)

Catch me if you can! Oxidative protein trapping in the intermembrane space of mitochondria
por: Herrmann, Johannes M., et al.
Publicado: (2007)

Proteasomal degradation induced by DPP9‐mediated processing competes with mitochondrial protein import
por: Finger, Yannik, et al.
Publicado: (2020)

Protocol for engineering and validating a synthetic mitochondrial intermembrane bridge in mammalian cells
por: Purohit, Gunjan, et al.
Publicado: (2022)

A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding
por: Sideris, Dionisia P., et al.
Publicado: (2009)

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins
por: Kowalski, Lukasz, et al.
Publicado: (2018)

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space
por: Manganas, Phanee, et al.
Publicado: (2016)

Myristoyl group-aided protein import into the mitochondrial intermembrane space
por: Ueda, Eri, et al.
Publicado: (2019)

An intermembrane space protein facilitates completion of mitochondrial division in yeast
por: Connor, Olivia M., et al.
Publicado: (2023)

DNA nanostructure‐programmed intermembrane spacing to modulate T‐cell immunity
por: Du, Yulin, et al.
Publicado: (2023)

To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay
por: Carrie, Chris, et al.
Publicado: (2017)

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space
por: Weinhäupl, Katharina, et al.
Publicado: (2018)

Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease
por: MacPherson, Lisa, et al.
Publicado: (2017)

Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging
por: Vega, Montserrat, et al.
Publicado: (2022)

The mitochondrial intermembrane space–facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism
por: Odendall, Fenja, et al.
Publicado: (2019)

Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding
por: Peleh, Valentina, et al.
Publicado: (2016)

Quantifying Intermembrane Distances with Serial Image Dilations
por: Raisch, Tristan, et al.
Publicado: (2018)

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
por: Adriaenssens, Elias, et al.
Publicado: (2023)

Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40
por: Peleh, Valentina, et al.
Publicado: (2017)

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria
por: Gornicka, Agnieszka, et al.
Publicado: (2014)

Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli
por: Vetterli, Stefan U., et al.
Publicado: (2018)

Stop wasting protein—Proteasome inhibition to target diseases linked to mitochondrial import
por: Habich, Markus, et al.
Publicado: (2019)

Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space
por: Cardenas‐Rodriguez, Mauricio, et al.
Publicado: (2017)

Chloroplast import of an intermembrane space protein is facilitated by translocon components Toc75 and Tic236
por: Chuang, Meng‐Rong, et al.
Publicado: (2021)

CUP1 Metallothionein from Healthy Saccharomyces cerevisiae Colocalizes to the Cytosol and Mitochondrial Intermembrane Space
por: Kim, Joshua E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dfce9o8u621c9v1ed062pmvj2r