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Instantaneous inactivation of cofilin reveals its function of F-actin disassembly in lamellipodia

Cofilin is a key regulator of the actin cytoskeleton. It can sever actin filaments, accelerate filament disassembly, act as a nucleation factor, recruit or antagonize other actin regulators, and control the pool of polymerization-competent actin monomers. In cells these actions have complex function...

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Detalles Bibliográficos
Autores principales: Vitriol, Eric A., Wise, Ariel L., Berginski, Mathew E., Bamburg, James R., Zheng, James Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708729/
https://www.ncbi.nlm.nih.gov/pubmed/23676663
http://dx.doi.org/10.1091/mbc.E13-03-0156