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Dispelling urban myths about default uncertainty factors in chemical risk assessment – sufficient protection against mixture effects?

Assessing the detrimental health effects of chemicals requires the extrapolation of experimental data in animals to human populations. This is achieved by applying a default uncertainty factor of 100 to doses not found to be associated with observable effects in laboratory animals. It is commonly as...

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Detalles Bibliográficos
Autores principales: Martin, Olwenn V, Martin, Scholze, Andreas, Kortenkamp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708776/
https://www.ncbi.nlm.nih.gov/pubmed/23816180
http://dx.doi.org/10.1186/1476-069X-12-53