Structure and Function of a Fungal Adhesin that Binds Heparin and Mimics Thrombospondin-1 by Blocking T Cell Activation and Effector Function

Blastomyces adhesin-1 (BAD-1) is a 120-kD surface protein on B. dermatitidis yeast. We show here that BAD-1 contains 41 tandem repeats and that deleting even half of them impairs fungal pathogenicity. According to NMR, the repeats form tightly folded 17-amino acid loops constrained by a disulfide bo...

Descripción completa

Detalles Bibliográficos
Autores principales: Brandhorst, T. Tristan, Roy, René, Wüthrich, Marcel, Nanjappa, Som, Filutowicz, Hanna, Galles, Kevin, Tonelli, Marco, McCaslin, Darrell R., Satyshur, Kenneth, Klein, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708853/
https://www.ncbi.nlm.nih.gov/pubmed/23853587
http://dx.doi.org/10.1371/journal.ppat.1003464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708853/
https://www.ncbi.nlm.nih.gov/pubmed/23853587
http://dx.doi.org/10.1371/journal.ppat.1003464

Ejemplares similares