Cargando…

Structure and Function of a Fungal Adhesin that Binds Heparin and Mimics Thrombospondin-1 by Blocking T Cell Activation and Effector Function

Blastomyces adhesin-1 (BAD-1) is a 120-kD surface protein on B. dermatitidis yeast. We show here that BAD-1 contains 41 tandem repeats and that deleting even half of them impairs fungal pathogenicity. According to NMR, the repeats form tightly folded 17-amino acid loops constrained by a disulfide bo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brandhorst, T. Tristan, Roy, René, Wüthrich, Marcel, Nanjappa, Som, Filutowicz, Hanna, Galles, Kevin, Tonelli, Marco, McCaslin, Darrell R., Satyshur, Kenneth, Klein, Bruce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708853/ https://www.ncbi.nlm.nih.gov/pubmed/23853587 http://dx.doi.org/10.1371/journal.ppat.1003464

Ejemplares similares

Targeted Gene Disruption Reveals an Adhesin Indispensable for Pathogenicity of Blastomyces dermatitidis
por: Tristan Brandhorst, T., et al.
Publicado: (1999)

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia
por: Nanjappa, Som Gowda, et al.
Publicado: (2015)

Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase
por: Beaussart, Audrey, et al.
Publicado: (2015)

Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells
por: Nanjappa, Som Gowda, et al.
Publicado: (2017)

Dual function of a bacterial protein as an adhesin and extracellular effector of host GTPase signaling
por: Stones, Daniel Henry, et al.
Publicado: (2015)

Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination
por: Wang, Huafeng, et al.
Publicado: (2017)

Tc17 Cells Mediate Vaccine Immunity against Lethal Fungal Pneumonia in Immune Deficient Hosts Lacking CD4(+) T Cells
por: Nanjappa, Som Gowda, et al.
Publicado: (2012)

Thrombospondins function as regulators of angiogenesis
por: Bornstein, Paul
Publicado: (2009)

Diagnostic Value of Recombinant Heparin-binding Hemagglutinin Adhesin Protein in Spinal Tuberculosis
por: Pu, Feifei, et al.
Publicado: (2020)

Large tender abdominal aortic aneurysm presented with concomitant acute appendicitis: a case report
por: Al Samaraee, Ahmad, et al.
Publicado: (2009)

1966 CERN LRL RHEL shielding experiment at the CERN proton synchrotron
por: Gilbert, William S, et al.
Publicado: (1968)

Differential Contribution of the Repeats to Heparin Binding of HBHA, a Major Adhesin of Mycobacterium tuberculosis
por: Lebrun, Pierre, et al.
Publicado: (2012)

Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria
por: Raze, Dominique, et al.
Publicado: (2018)

Functions of Thrombospondin-1 in the Tumor Microenvironment
por: Kaur, Sukhbir, et al.
Publicado: (2021)

The Chlamydia trachomatis type III-secreted effector protein CteG induces centrosome amplification through interactions with centrin-2
por: Steiert, Brianna, et al.
Publicado: (2023)

Editorial: Immune intervention avenues to control fungal infections in immunocompromised individuals
por: Nanjappa, Som G.
Publicado: (2023)

Long‐distance natal dispersal is relatively frequent and correlated with environmental factors in a widespread raptor
por: McCaslin, Hanna M., et al.
Publicado: (2020)

Acute Limb Ischaemia and a Disguised Pseudoaneurysm: A Rare Presentation of a Femoral Osteochondroma
por: Rodham, Paul, et al.
Publicado: (2019)

Vaccine Immunity to Pathogenic Fungi Overcomes the Requirement for CD4 Help in Exogenous Antigen Presentation to CD8(+) T Cells: Implications for Vaccine Development in Immune-deficient Hosts
por: Wüthrich, Marcel, et al.
Publicado: (2003)

New Insights into the Methylation of Mycobacterium tuberculosis Heparin Binding Hemagglutinin Adhesin Expressed in Rhodococcus erythropolis
por: Parada, Cristina, et al.
Publicado: (2021)

Determination of the mimic epitope of the M-like protein adhesin in swine Streptococcus equi subsp. zooepidemicus
por: Fan, Hongjie, et al.
Publicado: (2008)

Thrombospondins in the heart: potential functions in cardiac remodeling
por: Schellings, Mark W. M., et al.
Publicado: (2009)

FaaPred: A SVM-Based Prediction Method for Fungal Adhesins and Adhesin-Like Proteins
por: Ramana, Jayashree, et al.
Publicado: (2010)

Mechanisms and competition of halide substitution and hydrolysis in reactions of N(2)O(5) with seawater
por: McCaslin, Laura M., et al.
Publicado: (2019)

New adhesin functions of surface-exposed pneumococcal proteins
por: Frolet, Cécile, et al.
Publicado: (2010)

Yersinia infection tools—characterization of structure and function of adhesins
por: Mikula, Kornelia M., et al.
Publicado: (2013)

Adhesins in the virulence of opportunistic fungal pathogens of human
por: Kumari, Amrita, et al.
Publicado: (2021)

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis
por: Kujoth, Gregory C., et al.
Publicado: (2018)

Aggressive Endovascular Management of Massive Dural Venous Sinus Thrombosis in the Setting of Acute Myeloid Leukemia
por: Haider, Ali S, et al.
Publicado: (2019)

Sustainable polycarbonate adhesives for dry and aqueous conditions with thermoresponsive properties
por: Beharaj, Anjeza, et al.
Publicado: (2019)

Specific metallo-protein interactions and antimicrobial activity in Histatin-5, an intrinsically disordered salivary peptide
por: McCaslin, Tyler G., et al.
Publicado: (2019)

T cell responses to control fungal infection in an immunological memory lens
por: Sharma, Jaishree, et al.
Publicado: (2022)

Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1
Publicado: (1995)

FungalRV: adhesin prediction and immunoinformatics portal for human fungal pathogens
por: Chaudhuri, Rupanjali, et al.
Publicado: (2011)

Active Sugar Transport by the Small Intestine : The effects of sugars, amino acids, hexosamines, sulfhydryl-reacting compounds, and cations on the preferential binding of D-glucose to Tris-disrupted brush borders
por: Faust, Robert G., et al.
Publicado: (1968)

Health physics manual of good practices for accelerator facilities
por: Casey, W R, et al.
Publicado: (1988)

Thrombospondins and synaptogenesis★
por: Wang, Bin, et al.
Publicado: (2012)

The Human Disease-Associated Aβ Amyloid Core Sequence Forms Functional Amyloids in a Fungal Adhesin
por: Rameau, Rachele D., et al.
Publicado: (2016)

Structure and functional analysis of a bacterial adhesin sugar-binding domain
por: Vance, Tyler D. R., et al.
Publicado: (2019)

Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)
por: Zhang, Kaijie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4cq2g4jrfe5vjgu5n9n1nh0ld5