Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis

Nef is the viral gene product employed by the majority of primate lentiviruses to overcome restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that inhibits the detachment of enveloped viruses from infected cells. Although the mechanisms of tetherin antagonism by...

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Detalles Bibliográficos
Autores principales: Serra-Moreno, Ruth, Zimmermann, Kerstin, Stern, Lawrence J., Evans, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708871/
https://www.ncbi.nlm.nih.gov/pubmed/23853598
http://dx.doi.org/10.1371/journal.ppat.1003487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708871/
https://www.ncbi.nlm.nih.gov/pubmed/23853598
http://dx.doi.org/10.1371/journal.ppat.1003487

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