Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation

The sterile alpha motif (SAM) and HD domain-containing protein-1 (SAMHD1) inhibits the infection of resting CD4+ T cells and myeloid cells by human and related simian immunodeficiency viruses (HIV and SIV). Vpx inactivates SAMHD1 by promoting its proteasome-dependent degradation through an interacti...

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Detalles Bibliográficos
Autores principales: Guo, Haoran, Wei, Wei, Wei, Zhenhong, Liu, Xianjun, Evans, Sean L., Yang, Weiming, Wang, Hong, Guo, Ying, Zhao, Ke, Zhou, Jian-Ying, Yu, Xiao-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708934/
https://www.ncbi.nlm.nih.gov/pubmed/23874389
http://dx.doi.org/10.1371/journal.pone.0066201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708934/
https://www.ncbi.nlm.nih.gov/pubmed/23874389
http://dx.doi.org/10.1371/journal.pone.0066201

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