Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations

The Birt-Hogg-Dube disease occurs as a result of germline mutations in the human Folliculin gene (FLCN), and is characterized by clinical features including fibrofolliculomas, lung cysts and multifocal renal neoplasia. Clinical and genetic evidence suggest that FLCN acts as a tumor suppressor gene....

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Detalles Bibliográficos
Autores principales: Laviolette, Laura A., Wilson, Jonas, Koller, Julia, Neil, Christopher, Hulick, Peter, Rejtar, Tomas, Karger, Barry, Teh, Bin Tean, Iliopoulos, Othon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708955/
https://www.ncbi.nlm.nih.gov/pubmed/23874397
http://dx.doi.org/10.1371/journal.pone.0066775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708955/
https://www.ncbi.nlm.nih.gov/pubmed/23874397
http://dx.doi.org/10.1371/journal.pone.0066775

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