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Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations
The Birt-Hogg-Dube disease occurs as a result of germline mutations in the human Folliculin gene (FLCN), and is characterized by clinical features including fibrofolliculomas, lung cysts and multifocal renal neoplasia. Clinical and genetic evidence suggest that FLCN acts as a tumor suppressor gene....
Autores principales: | Laviolette, Laura A., Wilson, Jonas, Koller, Julia, Neil, Christopher, Hulick, Peter, Rejtar, Tomas, Karger, Barry, Teh, Bin Tean, Iliopoulos, Othon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708955/ https://www.ncbi.nlm.nih.gov/pubmed/23874397 http://dx.doi.org/10.1371/journal.pone.0066775 |
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