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HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype

AIMS: Owing to strong linkage disequilibrium between markers, pinpointing disease associations within genetic regions is difficult in European ancestral populations, most notably the very strong association of the HLA-DRB1*03-DQA1*05:01-DQB1*02:01 haplotype with Type 1 diabetes risk, which is assume...

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Detalles Bibliográficos
Autores principales: Howson, J M M, Roy, M S, Zeitels, L, Stevens, H, Todd, J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709123/
https://www.ncbi.nlm.nih.gov/pubmed/23398374
http://dx.doi.org/10.1111/dme.12148