Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

The recent identification of the mitochondrial Ca(2+) uniporter gene (Mcu/Ccdc109a) has enabled us to address its role, and that of mitochondrial Ca(2+) uptake, in neuronal excitotoxicity. Here we show that exogenously expressed Mcu is mitochondrially localized and increases mitochondrial Ca(2+) lev...

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Detalles Bibliográficos
Autores principales: Qiu, Jing, Tan, Yan-Wei, Hagenston, Anna M., Martel, Marc-Andre, Kneisel, Niclas, Skehel, Paul A., Wyllie, David J. A., Bading, Hilmar, Hardingham, Giles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709514/
https://www.ncbi.nlm.nih.gov/pubmed/23774321
http://dx.doi.org/10.1038/ncomms3034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709514/
https://www.ncbi.nlm.nih.gov/pubmed/23774321
http://dx.doi.org/10.1038/ncomms3034

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