A Novel Perspective and Approach to Intestinal Octreotide Absorption: Sinomenine-Mediated Reversible Tight Junction Opening and Its Molecular Mechanism

In this work, we assessed the effects of sinomenine (SN) on intestinal octreotide (OCT) absorption both in Caco-2 cell monolayers and in rats. We also investigated the molecular mechanisms of tight junction (TJ) disruption and recovery by SN-mediated changes in the claudin-1 and protein kinase C (PK...

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Detalles Bibliográficos
Autores principales: Li, Yuling, Duan, Zhijun, Tian, Yan, Liu, Zhen, Wang, Qiuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709818/
https://www.ncbi.nlm.nih.gov/pubmed/23787475
http://dx.doi.org/10.3390/ijms140612873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709818/
https://www.ncbi.nlm.nih.gov/pubmed/23787475
http://dx.doi.org/10.3390/ijms140612873

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