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An Apoptosis-Associated Mammary Protein Deficiency Leads to Enhanced Production of IgM Antibodies against Multiple Damage-Associated Molecules

Milk fat globule epidermal growth factor 8 (MFG-E8) is a protein that binds to apoptotic cells by recognizing phosphatidylserine and enhances the engulfment of apoptotic cells by macrophages. Many apoptotic cells are left unengulfed in the germinal centers of the spleen in the MFG-E8-deficient (MFG-...

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Detalles Bibliográficos
Autores principales: Chikazawa, Miho, Otaki, Natsuki, Shibata, Takahiro, Yasueda, Takehiko, Matsuda, Tsukasa, Uchida, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709889/
https://www.ncbi.nlm.nih.gov/pubmed/23874637
http://dx.doi.org/10.1371/journal.pone.0068468