Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5′ and 3′ termini. To date, the function of these tRNA fragments (tRFs) derived from the 5′ end of tRNA has not been investigated in depth. We present evidence that conserved residues in t...

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Detalles Bibliográficos
Autores principales: Sobala, Andrew, Hutvagner, Gyorgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710361/
https://www.ncbi.nlm.nih.gov/pubmed/23563448
http://dx.doi.org/10.4161/rna.24285
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author Sobala, Andrew
Hutvagner, Gyorgy
author_facet Sobala, Andrew
Hutvagner, Gyorgy
author_sort Sobala, Andrew
collection PubMed
description Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5′ and 3′ termini. To date, the function of these tRNA fragments (tRFs) derived from the 5′ end of tRNA has not been investigated in depth. We present evidence that conserved residues in tRNA, present in all 5′ tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5′ tRFs in a new mechanism of gene regulation by small RNAs in human cells.
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spelling pubmed-37103612013-07-25 Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells Sobala, Andrew Hutvagner, Gyorgy RNA Biol Research Paper Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5′ and 3′ termini. To date, the function of these tRNA fragments (tRFs) derived from the 5′ end of tRNA has not been investigated in depth. We present evidence that conserved residues in tRNA, present in all 5′ tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5′ tRFs in a new mechanism of gene regulation by small RNAs in human cells. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3710361/ /pubmed/23563448 http://dx.doi.org/10.4161/rna.24285 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Research Paper
Sobala, Andrew
Hutvagner, Gyorgy
Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells
title Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells
title_full Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells
title_fullStr Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells
title_full_unstemmed Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells
title_short Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells
title_sort small rnas derived from the 5′ end of trna can inhibit protein translation in human cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710361/
https://www.ncbi.nlm.nih.gov/pubmed/23563448
http://dx.doi.org/10.4161/rna.24285
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