Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites

Genome instability is a hallmark of cancer. Common fragile sites (CFSs) are specific regions in the human genome that are sensitive to replication stress and are prone to genomic instability in different cancer types. Here we molecularly cloned a new CFS, FRA11H, in 11q13. The genomic region of FRA1...

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Detalles Bibliográficos
Autores principales: Bester, Assaf C., Kafri, Moshe, Maoz, Karin, Kerem, Batsheva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711054/
https://www.ncbi.nlm.nih.gov/pubmed/23852038
http://dx.doi.org/10.1038/srep02189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711054/
https://www.ncbi.nlm.nih.gov/pubmed/23852038
http://dx.doi.org/10.1038/srep02189

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