α-Tropomyosin with a D175N or E180G Mutation in Only One Chain Differs from Tropomyosin with Mutations in Both Chains

[Image: see text] α-Tropomyosin (Tm) carrying hypertrophic cardiomyopathy mutation D175N or E180G was expressed in Escherichia coli. We have assembled dimers of two polypeptide chains in vitro that carry one (αα*) or two (α*α*) copies of the mutation. We found that the presence of the mutation has l...

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Detalles Bibliográficos
Autores principales: Janco, Miro, Kalyva, Athanasia, Scellini, Beatrice, Piroddi, Nicoletta, Tesi, Chiara, Poggesi, Corrado, Geeves, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711130/
https://www.ncbi.nlm.nih.gov/pubmed/23170982
http://dx.doi.org/10.1021/bi301323n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711130/
https://www.ncbi.nlm.nih.gov/pubmed/23170982
http://dx.doi.org/10.1021/bi301323n

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