Kinase Inhibitor Sorafenib Modulates Immunosuppressive Cell Populations in a Murine Liver Cancer Model

Accumulating evidence suggests that regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSC) are elevated in cancer patients and tumor-bearing hosts, and that depletion of Tregs and MDSC may enhance the anti-tumor immunity of the host. Sorafenib, a novel multikinase inhibitor, is appro...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Mengde, Xu, Yiling, Youn, Je-in, Cabrera, Roniel, Zhang, Xiaokui, Gabrilovich, Dmitry, Nelson, David R., Liu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711234/
https://www.ncbi.nlm.nih.gov/pubmed/21321535
http://dx.doi.org/10.1038/labinvest.2010.205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711234/
https://www.ncbi.nlm.nih.gov/pubmed/21321535
http://dx.doi.org/10.1038/labinvest.2010.205

Ejemplares similares