Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

OBJECTIVE: Interleukin (IL)-7 is mainly produced in bone marrow (BM) that forms the niche for B cells. We previously demonstrated that BM also retains pathogenic memory CD4 T cells in murine models of inflammatory bowel disease (IBD). However, it remains unknown whether BM-derived IL-7 is sufficient...

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Detalles Bibliográficos
Autores principales: Nemoto, Yasuhiro, Kanai, Takanori, Takahara, Masahiro, Oshima, Shigeru, Nakamura, Tetsuya, Okamoto, Ryuichi, Tsuchiya, Kiichiro, Watanabe, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2013
Materias:
Inflammatory Bowel Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711361/
https://www.ncbi.nlm.nih.gov/pubmed/23144054
http://dx.doi.org/10.1136/gutjnl-2012-302029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711361/
https://www.ncbi.nlm.nih.gov/pubmed/23144054
http://dx.doi.org/10.1136/gutjnl-2012-302029

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