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IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG)

The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) controls the migration and invasiveness of primary as well as tumor-derived cells in vitro. Whether the protein also modulates epithelial-mesenchymal-transition (EMT), a hallmark of tumor progression involved in tumor cell dissemination, remained e...

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Detalles Bibliográficos
Autores principales:	Zirkel, Anne, Lederer, Marcell, Stöhr, Nadine, Pazaitis, Nikolaos, Hüttelmaier, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711427/ https://www.ncbi.nlm.nih.gov/pubmed/23677615 http://dx.doi.org/10.1093/nar/gkt410

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