Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation

Caffeine is a widely used inhibitor of the protein kinases that play a central role in the DNA damage response. We used chemical inhibitors and genetically deficient mouse embryonic stem cell lines to study the role of DNA damage response in stable integration of the transfected DNA and found that c...

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Detalles Bibliográficos
Autores principales: Zelensky, Alex N., Sanchez, Humberto, Ristic, Dejan, Vidic, Iztok, van Rossum-Fikkert, Sari E., Essers, Jeroen, Wyman, Claire, Kanaar, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711438/
https://www.ncbi.nlm.nih.gov/pubmed/23666627
http://dx.doi.org/10.1093/nar/gkt375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711438/
https://www.ncbi.nlm.nih.gov/pubmed/23666627
http://dx.doi.org/10.1093/nar/gkt375

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