Single-molecule study of the CUG repeat–MBNL1 interaction and its inhibition by small molecules

Effective drug discovery and optimization can be accelerated by techniques capable of deconvoluting the complexities often present in targeted biological systems. We report a single-molecule approach to study the binding of an alternative splicing regulator, muscleblind-like 1 protein (MBNL1), to (C...

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Detalles Bibliográficos
Autores principales: Haghighat Jahromi, Amin, Honda, Masayoshi, Zimmerman, Steven C., Spies, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711446/
https://www.ncbi.nlm.nih.gov/pubmed/23661680
http://dx.doi.org/10.1093/nar/gkt330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711446/
https://www.ncbi.nlm.nih.gov/pubmed/23661680
http://dx.doi.org/10.1093/nar/gkt330

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