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Single-molecule study of the CUG repeat–MBNL1 interaction and its inhibition by small molecules
Effective drug discovery and optimization can be accelerated by techniques capable of deconvoluting the complexities often present in targeted biological systems. We report a single-molecule approach to study the binding of an alternative splicing regulator, muscleblind-like 1 protein (MBNL1), to (C...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711446/ https://www.ncbi.nlm.nih.gov/pubmed/23661680 http://dx.doi.org/10.1093/nar/gkt330 |