Telomere Position Effect (TPE) Regulates DUX4 in Human Facioscapulohumeral Muscular Dystrophy (FSHD)

Telomeres may regulate human disease by at least two independent mechanisms. 1) Replicative senescence occurs once short telomeres generate DNA damage signals that produce a barrier to tumor progression. 2) Telomere Position Effect (TPE) can change gene expression at intermediate telomere lengths in...

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Detalles Bibliográficos
Autores principales: Stadler, Guido, Rahimov, Fedik, King, Oliver D., Chen, Jennifer C. J., Robin, Jerome D., Wagner, Kathryn R., Shay, Jerry W., Emerson, Charles P., Wright, Woodring E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711615/
https://www.ncbi.nlm.nih.gov/pubmed/23644600
http://dx.doi.org/10.1038/nsmb.2571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711615/
https://www.ncbi.nlm.nih.gov/pubmed/23644600
http://dx.doi.org/10.1038/nsmb.2571

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