The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?

Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci...

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Detalles Bibliográficos
Autores principales: Hall, Matthew D, Ebert, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711976/
https://www.ncbi.nlm.nih.gov/pubmed/23855805
http://dx.doi.org/10.1186/1741-7007-11-79
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author Hall, Matthew D
Ebert, Dieter
author_facet Hall, Matthew D
Ebert, Dieter
author_sort Hall, Matthew D
collection PubMed
description Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have been overestimated.
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spelling pubmed-37119762013-07-16 The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? Hall, Matthew D Ebert, Dieter BMC Biol Opinion Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have been overestimated. BioMed Central 2013-07-15 /pmc/articles/PMC3711976/ /pubmed/23855805 http://dx.doi.org/10.1186/1741-7007-11-79 Text en Copyright © 2013 Hall and Ebert; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Opinion
Hall, Matthew D
Ebert, Dieter
The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
title The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
title_full The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
title_fullStr The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
title_full_unstemmed The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
title_short The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
title_sort genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711976/
https://www.ncbi.nlm.nih.gov/pubmed/23855805
http://dx.doi.org/10.1186/1741-7007-11-79
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