Signaling pathway switch in breast cancer

Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway i...

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Detalles Bibliográficos
Autores principales: Guille, Arnaud, Chaffanet, Max, Birnbaum, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712008/
https://www.ncbi.nlm.nih.gov/pubmed/23805779
http://dx.doi.org/10.1186/1475-2867-13-66
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author Guille, Arnaud
Chaffanet, Max
Birnbaum, Daniel
author_facet Guille, Arnaud
Chaffanet, Max
Birnbaum, Daniel
author_sort Guille, Arnaud
collection PubMed
description Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells
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spelling pubmed-37120082013-07-16 Signaling pathway switch in breast cancer Guille, Arnaud Chaffanet, Max Birnbaum, Daniel Cancer Cell Int Hypothesis Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells BioMed Central 2013-06-27 /pmc/articles/PMC3712008/ /pubmed/23805779 http://dx.doi.org/10.1186/1475-2867-13-66 Text en Copyright © 2013 Guille et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis
Guille, Arnaud
Chaffanet, Max
Birnbaum, Daniel
Signaling pathway switch in breast cancer
title Signaling pathway switch in breast cancer
title_full Signaling pathway switch in breast cancer
title_fullStr Signaling pathway switch in breast cancer
title_full_unstemmed Signaling pathway switch in breast cancer
title_short Signaling pathway switch in breast cancer
title_sort signaling pathway switch in breast cancer
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712008/
https://www.ncbi.nlm.nih.gov/pubmed/23805779
http://dx.doi.org/10.1186/1475-2867-13-66
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