Cargando…

In Vivo JNK Activation in Pancreatic β-Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas

Insulin resistance is a key condition in the development of type 2 diabetes. It is well established that exacerbated Jun NH(2)-terminal kinase (JNK) activity is involved in promoting insulin resistance in peripheral insulin-target tissues; however, this involvement is less documented in pancreatic β...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lanuza-Masdeu, Jordi, Arévalo, M. Isabel, Vila, Cristina, Barberà, Albert, Gomis, Ramon, Caelles, Carme
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712047/ https://www.ncbi.nlm.nih.gov/pubmed/23349497 http://dx.doi.org/10.2337/db12-1097

Ejemplares similares

Distinct Responses to IL4 in Macrophages Mediated by JNK
por: Arpa, Luís, et al.
Publicado: (2023)

Investigation of insulin clearance in septic patients with glucose intolerance: analysis under strict blood glucose control by means of artificial pancreas
por: Hoshino, M, et al.
Publicado: (2001)

Investigation of the factors which influence insulin sensitivity in septic patients with glucose intolerance: analysis with glucose clamp method by means of artificial pancreas
por: Hoshino, M, et al.
Publicado: (2002)

FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization
por: Kikuchi, Osamu, et al.
Publicado: (2012)

Investigation of insulin clearance in severely acutely ill patients with glucose intolerance evaluated by means of bedside-type artificial pancreas
por: Hoshino, M, et al.
Publicado: (2007)

Blueberries’ Impact on Insulin Resistance and Glucose Intolerance
por: Stull, April J.
Publicado: (2016)

Evaluation of glucose intolerance in acutely ill severe patients by means of an artificial pancreas
por: Hoshino, M, et al.
Publicado: (2004)

Glucocorticoids Antagonize Ap-1 by Inhibiting the Activation/Phosphorylation of Jnk without Affecting Its Subcellular Distribution
por: González, María Victoria, et al.
Publicado: (2000)

Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice
por: Fang, Zhiqiang, et al.
Publicado: (2023)

Glucose Homeostatic Law: Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans
por: Ohashi, Kaoru, et al.
Publicado: (2015)

Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia
por: Ramanathan, Ranjani P., et al.
Publicado: (2011)

β-Cell dysfunction and insulin resistance in gestational glucose intolerance
por: Jang, Eun-Hee, et al.
Publicado: (2013)

Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men
por: Nishii, Takasei, et al.
Publicado: (2001)

Insulin Resistant Gestational Glucose Intolerance Is Associated With Adverse Perinatal Outcomes
por: Selen, Daryl J, et al.
Publicado: (2021)

Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
por: Wright, Jordan J., et al.
Publicado: (2023)

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
por: Yang, Shi-Bing, et al.
Publicado: (2011)

Neuroprotective role of PrP(C) against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7–PSD-95 binding
por: Carulla, Patricia, et al.
Publicado: (2011)

Significance of the suppression of blood glucose variability in acutely ill severe patients with glucose intolerance evaluated by means of bedside-type artificial pancreas
por: Hoshino, M, et al.
Publicado: (2008)

Arsenic Exposure and Glucose Intolerance/Insulin Resistance in Estrogen-Deficient Female Mice
por: Huang, Chun-Fa, et al.
Publicado: (2015)

Prediction of glucose intolerance at 24-28 weeks of gestation by glucose and insulin level measurements in the first trimester
por: Fahami, Fariba, et al.
Publicado: (2015)

α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population
por: Gall, Walter E., et al.
Publicado: (2010)

Postprandial Hypertriglyceridemia Predicts Development of Insulin Resistance Glucose Intolerance and Type 2 Diabetes
por: Aslam, Mohammad, et al.
Publicado: (2016)

Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice
por: Diaz-Castroverde, Sabela, et al.
Publicado: (2016)

Sarcopoterium spinosum extract improved insulin sensitivity in mice models of glucose intolerance and diabetes
por: Rozenberg, Konstantin, et al.
Publicado: (2018)

Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance
por: Wang, Lin, et al.
Publicado: (2018)

Relationship between blood glucose level and outcome in acutely ill severe patients with glucose intolerance evaluated by means of a bedside-type artificial pancreas
por: Hoshino, M, et al.
Publicado: (2006)

Chronic Phase Shifts of the Photoperiod throughout Pregnancy Programs Glucose Intolerance and Insulin Resistance in the Rat
por: Varcoe, Tamara J., et al.
Publicado: (2011)

Association Between Serum Adipsin Levels and Insulin Resistance in Subjects With Various Degrees of Glucose Intolerance
por: Wang, Jun-Sing, et al.
Publicado: (2018)

Proinsulin is sensitive to reflect glucose intolerance
por: Nakamura, Akinobu, et al.
Publicado: (2019)

JNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function
por: Busquets, Oriol, et al.
Publicado: (2022)

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice
por: Isganaitis, Elvira, et al.
Publicado: (2014)

Insulin and the Diabetic Pancreas
por: Susman, William
Publicado: (1928)

Molecular mechanisms of tungstate-induced pancreatic plasticity: a transcriptomics approach
por: Altirriba, Jordi, et al.
Publicado: (2009)

Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design
por: Rhee, Yeong, et al.
Publicado: (2011)

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
por: Deprez-Poulain, Rebecca, et al.
Publicado: (2015)

Glucose Intolerance After Pancreatectomy Was Associated With Preoperative Hemoglobin A1c, Insulin Resistance, and Histological Pancreatic Fatty Infiltration
por: Ishibashi, Chisaki, et al.
Publicado: (2018)

Serum fibroblast growth factor 1 and its association with pancreatic beta cell function and insulin sensitivity in adults with glucose intolerance
por: Kim, Ji Yoon, et al.
Publicado: (2023)

Intestinal Ralstonia pickettii augments glucose intolerance in obesity
por: Udayappan, Shanthadevi D., et al.
Publicado: (2017)

METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
por: Kalyani, Rita, et al.
Publicado: (2022)

Optimal Testing for Diagnosis of Fructose Intolerance: Over-dosage Leads to False Positive Intolerance Test
por: Erdogan, Askin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pmo596hv2o6e2vbhh4ul5ibaa2