Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats

INTRODUCTION: The purpose of this study was to compare the histocompatibility of white (WMTA) and gray (GMTA) mineral trioxide aggregate mixed with 0.12% chlorhexidine (CHX) and distilled water (DW) in subcutaneous connective tissues of rats. MATERIALS AND METHODS: The freshly mixed WMTA and GMTA wi...

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Autores principales: Yavari, Hamid Reza, Shahi, Shahriar, Rahimi, Saeed, Shakouie, Sahar, Roshangar, Leila, Mesgari Abassi, Mehran, Sattari Khavas, Sahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Center for Endodontic Research 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712265/
https://www.ncbi.nlm.nih.gov/pubmed/23864873
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author Yavari, Hamid Reza
Shahi, Shahriar
Rahimi, Saeed
Shakouie, Sahar
Roshangar, Leila
Mesgari Abassi, Mehran
Sattari Khavas, Sahar
author_facet Yavari, Hamid Reza
Shahi, Shahriar
Rahimi, Saeed
Shakouie, Sahar
Roshangar, Leila
Mesgari Abassi, Mehran
Sattari Khavas, Sahar
author_sort Yavari, Hamid Reza
collection PubMed
description INTRODUCTION: The purpose of this study was to compare the histocompatibility of white (WMTA) and gray (GMTA) mineral trioxide aggregate mixed with 0.12% chlorhexidine (CHX) and distilled water (DW) in subcutaneous connective tissues of rats. MATERIALS AND METHODS: The freshly mixed WMTA and GMTA with CHX or DW were inserted in polyethylene tubes and implanted into dorsal subcutaneous connective tissue of 50 Wistar Albino rats; tissue biopsies were collected and were then examined histologically 7, 15, 30, 60 and 90 days after the implantation procedure. The histology results were scored from 1-4; score 4 was considered as the worst finding. Data were analyzed using one-way ANOVA tests. RESULTS: All experimented materials were tolerated well by the connective tissues after 90-day evaluation, except for the WMTA/CHX group that had significantly more mean inflammatory scores (P<0.001). There was a statistically significant difference in the mean inflammation grades between experimental groups in each interval (P<0.001). After 90 days, GMTA/CHX group had the lowest inflammatory score. CONCLUSION: Although adding CHX to WMTA produces significantly higher inflammatory response, it seems a suitable substitute for DW in combination with GMTA. Further research is necessary to recommend this mixture for clinical use.
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spelling pubmed-37122652013-07-17 Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats Yavari, Hamid Reza Shahi, Shahriar Rahimi, Saeed Shakouie, Sahar Roshangar, Leila Mesgari Abassi, Mehran Sattari Khavas, Sahar Iran Endod J Original Article INTRODUCTION: The purpose of this study was to compare the histocompatibility of white (WMTA) and gray (GMTA) mineral trioxide aggregate mixed with 0.12% chlorhexidine (CHX) and distilled water (DW) in subcutaneous connective tissues of rats. MATERIALS AND METHODS: The freshly mixed WMTA and GMTA with CHX or DW were inserted in polyethylene tubes and implanted into dorsal subcutaneous connective tissue of 50 Wistar Albino rats; tissue biopsies were collected and were then examined histologically 7, 15, 30, 60 and 90 days after the implantation procedure. The histology results were scored from 1-4; score 4 was considered as the worst finding. Data were analyzed using one-way ANOVA tests. RESULTS: All experimented materials were tolerated well by the connective tissues after 90-day evaluation, except for the WMTA/CHX group that had significantly more mean inflammatory scores (P<0.001). There was a statistically significant difference in the mean inflammation grades between experimental groups in each interval (P<0.001). After 90 days, GMTA/CHX group had the lowest inflammatory score. CONCLUSION: Although adding CHX to WMTA produces significantly higher inflammatory response, it seems a suitable substitute for DW in combination with GMTA. Further research is necessary to recommend this mixture for clinical use. Iranian Center for Endodontic Research 2009-01-07 2009 /pmc/articles/PMC3712265/ /pubmed/23864873 Text en © 2009, Iranian Center for Endodontic Research This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yavari, Hamid Reza
Shahi, Shahriar
Rahimi, Saeed
Shakouie, Sahar
Roshangar, Leila
Mesgari Abassi, Mehran
Sattari Khavas, Sahar
Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats
title Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats
title_full Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats
title_fullStr Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats
title_full_unstemmed Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats
title_short Connective Tissue Reaction to White and Gray MTA Mixed With Distilled Water or Chlorhexidine in Rats
title_sort connective tissue reaction to white and gray mta mixed with distilled water or chlorhexidine in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712265/
https://www.ncbi.nlm.nih.gov/pubmed/23864873
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