FAK-heterozygous mice display enhanced tumour angiogenesis

Genetic ablation of endothelial Focal Adhesion Kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularisation. Here we show that reduced stromal-FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T...

Descripción completa

Detalles Bibliográficos
Autores principales: Kostourou, Vassiliki, Lechertier, Tanguy, Reynolds, Louise E., Lees, Delphine M., Baker, Marianne, Jones, Dylan T., Tavora, Bernardo, Ramjaun, Antoine R., Birdsey, Graeme M., Robinson, Stephen D., Parsons, Maddy, Randi, Anna M., Hart, Ian R, Hodivala-Dilke, Kairbaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712492/
https://www.ncbi.nlm.nih.gov/pubmed/23799510
http://dx.doi.org/10.1038/ncomms3020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712492/
https://www.ncbi.nlm.nih.gov/pubmed/23799510
http://dx.doi.org/10.1038/ncomms3020

Ejemplares similares