Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice

PURPOSE: To determine the effects of mitochondrial targeting sequence (MTS) modified AAV gene delivery of wild-type human NADH dehydrogenase subunit 4 (ND4), mutated in most cases of the blinding disease Leber hereditary optic neuropathy (LHON), on the host mouse mitochondrial genome. METHODS: We in...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Hong, Mehta, Arpit, Wang, Gaofeng, Hauswirth, William W., Chiodo, Vince, Boye, Sanford L., Guy, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712668/
https://www.ncbi.nlm.nih.gov/pubmed/23869167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712668/
https://www.ncbi.nlm.nih.gov/pubmed/23869167

Ejemplares similares