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Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice

PURPOSE: To determine the effects of mitochondrial targeting sequence (MTS) modified AAV gene delivery of wild-type human NADH dehydrogenase subunit 4 (ND4), mutated in most cases of the blinding disease Leber hereditary optic neuropathy (LHON), on the host mouse mitochondrial genome. METHODS: We in...

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Detalles Bibliográficos
Autores principales:	Yu, Hong, Mehta, Arpit, Wang, Gaofeng, Hauswirth, William W., Chiodo, Vince, Boye, Sanford L., Guy, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712668/ https://www.ncbi.nlm.nih.gov/pubmed/23869167

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