Cargando…

Tumor-Promoting Circuits That Regulate a Cancer-Related Chemokine Cluster: Dominance of Inflammatory Mediators Over Oncogenic Alterations

Here, we investigated the relative contribution of genetic/signaling components versus microenvironmental factors to the malignancy phenotype. In this system, we took advantage of non-transformed fibroblasts that carried defined oncogenic modifications in Ras and/or p53. These cells were exposed to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leibovich-Rivkin, Tal, Buganim, Yosef, Solomon, Hilla, Meshel, Tsipi, Rotter, Varda, Ben-Baruch, Adit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712671/ https://www.ncbi.nlm.nih.gov/pubmed/24213226 http://dx.doi.org/10.3390/cancers4010055

Ejemplares similares

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells
por: Leibovich-Rivkin, Tal, et al.
Publicado: (2014)

Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment
por: Weitzenfeld, Polina, et al.
Publicado: (2013)

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs()()
por: Lebel-Haziv, Yaeli, et al.
Publicado: (2014)

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
por: Soria, Gali, et al.
Publicado: (2011)

Microenvironmental networks promote tumor heterogeneity and enrich for metastatic cancer stem-like cells in Luminal-A breast tumor cells
por: Weitzenfeld, Polina, et al.
Publicado: (2016)

Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes
por: Erlichman, Nofar, et al.
Publicado: (2022)

Correction: Erlichman et al. Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes. Cancers 2022, 14, 1042
por: Erlichman, Nofar, et al.
Publicado: (2022)

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer
por: Liubomirski, Yulia, et al.
Publicado: (2019)

Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer
por: Baram, Tamir, et al.
Publicado: (2022)

Modulated expression of WFDC1 during carcinogenesis and cellular senescence
por: Madar, Shalom, et al.
Publicado: (2009)

A Tumor Microenvironment-Driven Network Regulated by STAT3 and p65 Negatively Controls the Enrichment of Cancer Stem Cells in Human HR+/HER2− Breast Cancer
por: Ben-Yaakov, Hagar, et al.
Publicado: (2023)

Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer
por: Tabach, Yuval, et al.
Publicado: (2011)

The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1
por: Erlichman, Nofar, et al.
Publicado: (2023)

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation
por: Aylon, Yael, et al.
Publicado: (2009)

Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells
por: Lerrer, Shalom, et al.
Publicado: (2017)

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer
por: Liubomirski, Yulia, et al.
Publicado: (2019)

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells
por: Morein, Dina, et al.
Publicado: (2021)

A Novel Translocation Breakpoint within the BPTF Gene Is Associated with a Pre-Malignant Phenotype
por: Buganim, Yosef, et al.
Publicado: (2010)

p53 and the Viral Connection: Back into the Future ‡
por: Aloni-Grinstein, Ronit, et al.
Publicado: (2018)

Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy
por: Morein, Dina, et al.
Publicado: (2020)

Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells
por: Rubinstein-Achiasaf, Linor, et al.
Publicado: (2021)

Chemotherapy Shifts the Balance in Favor of CD8+ TNFR2+ TILs in Triple-Negative Breast Tumors
por: Baram, Tamir, et al.
Publicado: (2021)

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway
por: Katanov, Christina, et al.
Publicado: (2015)

Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner
por: Charni-Natan, Meital, et al.
Publicado: (2018)

p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
por: Brosh, Ran, et al.
Publicado: (2008)

Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta
por: Madar, Shalom, et al.
Publicado: (2013)

Wide-Scale Analysis of Human Functional Transcription Factor Binding Reveals a Strong Bias towards the Transcription Start Site
por: Tabach, Yuval, et al.
Publicado: (2007)

Transdifferentiation by defined factors as a powerful research tool to address basic biological questions
por: Buganim, Yosef, et al.
Publicado: (2012)

Targeting mutant p53 for cancer therapy
por: Oren, Moshe, et al.
Publicado: (2016)

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy
por: Lonetto, Giuseppe, et al.
Publicado: (2018)

PHOX2B is a suppressor of neuroblastoma metastasis
por: Naftali, Osnat, et al.
Publicado: (2016)

Tumor Necrosis Factor α: Taking a Personalized Road in Cancer Therapy
por: Ben-Baruch, Adit
Publicado: (2022)

Hexokinase 2 is a determinant of neuroblastoma metastasis
por: Edry Botzer, Liat, et al.
Publicado: (2016)

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor
por: DeGeorge, Katharine C, et al.
Publicado: (2008)

The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy
por: Schlecht-Louf, Géraldine, et al.
Publicado: (2022)

Cystatin C takes part in melanoma-microglia cross-talk: possible implications for brain metastasis
por: Moshe, Adi, et al.
Publicado: (2018)

Dominant Myelopoietic Effector Functions Mediated by Chemokine Receptor CCR1
por: Broxmeyer, Hal E., et al.
Publicado: (1999)

Notch-Inflammation Networks in Regulation of Breast Cancer Progression
por: Liubomirski, Yulia, et al.
Publicado: (2020)

The link between emotion regulation and size estimation of spiders pictures among women with fear of spiders
por: Ben-Baruch, Yahel Dror, et al.
Publicado: (2022)

Dominant galaxies in bimodal clusters
por: Baier, F.W.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_95an9c387mj7nh4hmoo9v1fg9p