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Computational Insights into The Neuroprotective Action of Riluzole on 3-Acetylpyridine-Induced Ataxia in Rats

OBJECTIVE: Intra-peritoneal administration of riluzole has been shown to preserve the membrane properties and firing characteristics of Purkinje neurons in a rat model of cerebellar ataxia induced by 3-acetylpyridine (3-AP). However, the exact mechanism(s) by which riluzole restores the normal elect...

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Detalles Bibliográficos
Autores principales: Abbasi, Samira, Edrisi, Mehdi, Mahnam, Amin, Janahmadi, Mahyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712782/
https://www.ncbi.nlm.nih.gov/pubmed/23862110