The Serine/Threonine Phosphatase PP4 Is Required for Pro-B Cell Development through Its Promotion of Immunoglobulin VDJ Recombination

PP4 phosphatase regulates a number of crucial processes but the role of PP4 in B cells has never been reported. We generated B cell-specific pp4 knockout mice and have identified an essential role for PP4 in B cell development. Deficiency of PP4 in B lineage cells leads to a strong reduction in pre-...

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Detalles Bibliográficos
Autores principales: Su, Yu-wen, Chen, Ya-ping, Chen, Ming-yu, Reth, Michael, Tan, Tse-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712940/
https://www.ncbi.nlm.nih.gov/pubmed/23874770
http://dx.doi.org/10.1371/journal.pone.0068804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712940/
https://www.ncbi.nlm.nih.gov/pubmed/23874770
http://dx.doi.org/10.1371/journal.pone.0068804

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