Local Exome Sequences Facilitate Imputation of Less Common Variants and Increase Power of Genome Wide Association Studies

The analysis of less common variants in genome-wide association studies promises to elucidate complex trait genetics but is hampered by low power to reliably detect association. We show that addition of population-specific exome sequence data to global reference data allows more accurate imputation,...

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Detalles Bibliográficos
Autores principales: Joshi, Peter K., Prendergast, James, Fraser, Ross M., Huffman, Jennifer E., Vitart, Veronique, Hayward, Caroline, McQuillan, Ruth, Glodzik, Dominik, Polašek, Ozren, Hastie, Nicholas D., Rudan, Igor, Campbell, Harry, Wright, Alan F., Haley, Chris S., Wilson, James F., Navarro, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712964/
https://www.ncbi.nlm.nih.gov/pubmed/23874685
http://dx.doi.org/10.1371/journal.pone.0068604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712964/
https://www.ncbi.nlm.nih.gov/pubmed/23874685
http://dx.doi.org/10.1371/journal.pone.0068604

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