Oral Delivery of Lipophilic Drugs: The Tradeoff between Solubility Increase and Permeability Decrease When Using Cyclodextrin-Based Formulations

The purpose of this study was to investigate the impact of oral cyclodextrin-based formulation on both the apparent solubility and intestinal permeability of lipophilic drugs. The apparent solubility of the lipophilic drug dexamethasone was measured in the presence of various HPβCD levels. The drug’...

Descripción completa

Detalles Bibliográficos
Autores principales: Beig, Avital, Agbaria, Riad, Dahan, Arik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712970/
https://www.ncbi.nlm.nih.gov/pubmed/23874557
http://dx.doi.org/10.1371/journal.pone.0068237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712970/
https://www.ncbi.nlm.nih.gov/pubmed/23874557
http://dx.doi.org/10.1371/journal.pone.0068237

Ejemplares similares