Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression

The human AP-endonuclease (APE1/Ref-1), an essential multifunctional protein involved in repair of oxidative DNA damage as well as in transcriptional regulation, is often overexpressed in tumor cells. APE1 was earlier shown to stimulate p53’s DNA binding and its transactivation function in the expre...

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Detalles Bibliográficos
Autores principales: Sengupta, Shiladitya, Mitra, Sankar, Bhakat, Kishor K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713036/
https://www.ncbi.nlm.nih.gov/pubmed/23874636
http://dx.doi.org/10.1371/journal.pone.0068467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713036/
https://www.ncbi.nlm.nih.gov/pubmed/23874636
http://dx.doi.org/10.1371/journal.pone.0068467

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