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Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis
Chromosomal rearrangements can radically alter gene products and their function, driving tumor formation or progression. However, the molecular origins and evolution of such rearrangements are varied and poorly understood, with cancer cells often containing multiple, complex rearrangements. One mech...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713265/ https://www.ncbi.nlm.nih.gov/pubmed/23793898 http://dx.doi.org/10.1007/s10577-013-9368-6 |