Polyisoprenylated Methylated Protein Methyl Esterase Is Both Sensitive to Curcumin and Overexpressed in Colorectal Cancer: Implications for Chemoprevention and Treatment

Inhibition of PMPMEase, a key enzyme in the polyisoprenylation pathway, induces cancer cell death. In this study, purified PMPMEase was inhibited by the chemopreventive agent, curcumin, with a K (i) of 0.3 μM (IC(50) = 12.4 μM). Preincubation of PMPMEase with 1 mM curcumin followed by gel-filtration...

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Detalles Bibliográficos
Autores principales: Amissah, Felix, Duverna, Randolph, Aguilar, Byron J., Poku, Rosemary A., Lamango, Nazarius S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713324/
https://www.ncbi.nlm.nih.gov/pubmed/23936796
http://dx.doi.org/10.1155/2013/416534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713324/
https://www.ncbi.nlm.nih.gov/pubmed/23936796
http://dx.doi.org/10.1155/2013/416534

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