The insulin receptor cellular IRES confers resistance to eIF4A inhibition

Under conditions of stress, such as limited growth factor signaling, translation is inhibited by the action of 4E-BP and PDCD4. These proteins, through inhibition of eIF4E and eIF4A, respectively, impair cap-dependent translation. Under stress conditions FOXO transcription factors activate 4E-BP exp...

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Detalles Bibliográficos
Autores principales: Olson, Calla M, Donovan, Marissa R, Spellberg, Michael J, Marr, Michael T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713452/
https://www.ncbi.nlm.nih.gov/pubmed/23878722
http://dx.doi.org/10.7554/eLife.00542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713452/
https://www.ncbi.nlm.nih.gov/pubmed/23878722
http://dx.doi.org/10.7554/eLife.00542

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