Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family

The receptor tyrosine kinase Her2, an intensely pursued drug target, differs from other members of the EGFR family in that it does not bind EGF-like ligands, relying instead on heterodimerization with other (ligand-bound) EGFR-family receptors for activation. The structural basis for Her2 heterodime...

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Detalles Bibliográficos
Autores principales: Arkhipov, Anton, Shan, Yibing, Kim, Eric T, Dror, Ron O, Shaw, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713454/
https://www.ncbi.nlm.nih.gov/pubmed/23878723
http://dx.doi.org/10.7554/eLife.00708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713454/
https://www.ncbi.nlm.nih.gov/pubmed/23878723
http://dx.doi.org/10.7554/eLife.00708

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