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Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family
The receptor tyrosine kinase Her2, an intensely pursued drug target, differs from other members of the EGFR family in that it does not bind EGF-like ligands, relying instead on heterodimerization with other (ligand-bound) EGFR-family receptors for activation. The structural basis for Her2 heterodime...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713454/ https://www.ncbi.nlm.nih.gov/pubmed/23878723 http://dx.doi.org/10.7554/eLife.00708 |