MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. Here we show that MYBL2, a gene within the 20q CDR, is expressed at sharply reduced levels in C...

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Detalles Bibliográficos
Autores principales: Heinrichs, Stefan, Conover, Lillian F, Bueso-Ramos, Carlos E, Kilpivaara, Outi, Stevenson, Kristen, Neuberg, Donna, Loh, Mignon L, Wu, Wen-Shu, Rodig, Scott J, Garcia-Manero, Guillermo, Kantarjian, Hagop M, Look, A Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713455/
https://www.ncbi.nlm.nih.gov/pubmed/23878725
http://dx.doi.org/10.7554/eLife.00825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713455/
https://www.ncbi.nlm.nih.gov/pubmed/23878725
http://dx.doi.org/10.7554/eLife.00825

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